Treatment With Tamoxifen in Cryptococcal Meningitis
Status:
Completed
Trial end date:
2018-07-17
Target enrollment:
Participant gender:
Summary
The purpose of this study is to develop initial efficacy, feasibility, and safety data
regarding the use of Tamoxifen in combination with amphotericin B and fluconazole in the
treatment of cryptococcal meningitis. The results of the study will inform the design and
feasibility of a larger study powered to a survival endpoint. The study hypothesis is that
adding tamoxifen to standard antifungal therapy increases the rate of clearance of yeast from
cerebrospinal fluid. Increased rates of clearance of yeast from cerebrospinal fluid have
previously been associated with improved clinical outcomes, including survival and
disability.
Phase:
Phase 2
Details
Lead Sponsor:
Oxford University Clinical Research Unit, Vietnam
Collaborators:
Cho Ray Hospital Cho Ray Hospital, Ho Chi Minh City, Vietnam Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam Liverpool School of Tropical Medicine University of Liverpool University of Rochester
Treatments:
Amphotericin B Antifungal Agents Fluconazole Liposomal amphotericin B Miconazole Tamoxifen