Treatment for Calcium Phosphate Kidney Stone Disease

• Status: Recruiting
• Trial end date: 2022-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators will examine in two studies whether citric acid or potassium citrate can reduce calcium phosphate saturation in urine of Calcium Phosphate stone formers.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Texas Southwestern Medical Center
• Collaborator: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Treatments: Calcium, Dietary; Citric Acid; Indapamide; Potassium Citrate; Sodium Citrate

Criteria

Inclusion Criteria:

Aim 1

• Hypocitraturic CaP stone formers

• urine citrate <320mg/d

• elevated pH as 24-hr urine pH above 6.40

• >21 years

Aim 2

• Hypercalciuric CaP stone formers

• 24hr urine calcium >250mg/d in women and >300mg/d in men prior to indapamide use

• high pH as >6.40 in the absence of urinary tract infection

• >21 years