Treatment for Nicotine Addiction in Women

• Status: Completed
• Trial end date: 2019-06-30
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to use a medication tolcapone and or placebo to test if the symptoms of nicotine withdrawal lessens , and or changes in smoking urges, and mental reasoning in female smokers over a 72 hour period.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yale University
• Collaborators: National Institute on Drug Abuse (NIDA); US Department of Veterans Affairs; VA Office of Research and Development
• Treatments: Nicotine; Tolcapone

Criteria

Inclusion Criteria:

• Must be 18yrs to 45yr old woman, read and write in English.

• Must smoke at least 5 or more cigarettes a day

• FTND score at least 4 or higher

• A CO reading of 10 or higher during screening

• Must be in good health as verified by medical history, screening exam, screen laboratory tests.

Exclusion Criteria:

• Excluded if using psychotropic medications, have contraindications to tolcapone use (e.g.. liver problems, allergy to tolcapone, history of no traumatic rhabdomyolysis or hyperpyrexia, confusion possibly related to medication), have other substance use disorder, are pregnant or breast feeding, have a current psychotic disorder, bipolar disorder, homicidal or suicidal ideation, have current (past month) substance use disorder, other than nicotine dependence, or are unable to fulfill the scheduled visits and procedures.