Treatment in Patients With Globus: Psychoeducation, Anxiolytics or Proton Pump Inhibitors

• Status: Completed
• Trial end date: 2018-07-28
• Target enrollment: 0
• Participant gender: All

Summary

A randomized controlled trial study is conducted to compare treatment efficacy between psycho-education, anxiolytics drug and proton pump inhibitors in participants who met the criteria of globus.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mahidol University
• Treatments: Anti-Anxiety Agents; Flupenthixol; Flupenthixol decanoate; Omeprazole; Proton Pump Inhibitors

Criteria

Inclusion Criteria:

• Age ≥ 18 years

• Symptoms based on the following criteria: Persistent or intermittent nonpainful sensation of a lump or foreign body in the throat with no structural lesion identified on physical examination, laryngoscopy, or endoscopy.

1. Occurrence of the sensation between meals.

2. Absence of dysphagia or odynophagia

Exclusion Criteria:

• Subjects with psychological disease

• Significant heart disease and/or arrhythmia

• Proton Pump inhibitors and/or Histamine 2 Receptor Antagonist use within 2 weeks before randomization

• Mono-amine Oxidase inhibitors or Selective Serotonin Reuptake Inhibitor or Tricyclic antidepressant use within 2 weeks before randomization

• History of drug allergy that use in research

• Pregnancy or breast feeding

• Decline to participate in study