This study will compare the symptom relief provided by 5 cold medicines versus the symptom
relief provided by the same 5 cold medicines plus the antibiotic, amoxicillin, in people who
have sinus infections. Treatment with amoxicillin may be more effective than treatment with
cold medicines alone. Two hundred adult volunteers, aged 18 to 70 years old, with sinus
infections will participate in this study for 28 days. Volunteers will receive a 10-day
course of either amoxicillin or placebo (substance containing no medication). In addition,
all volunteers will receive pain medication, a chest decongestant, nasal decongestants, and
cough medicine as needed. Volunteers will be interviewed by telephone on days 0, 3, 7, 10,
and 28 following the start of treatment. The study will look at quality of life factors such
as change in functional status (ability to perform daily activities) and symptoms, recurrence
of the infection, satisfaction with care, and the direct costs of treatment.
Phase:
Phase 4
Details
Lead Sponsor:
Washington University School of Medicine
Collaborator:
National Institute of Allergy and Infectious Diseases (NIAID)