Treatment of Adiposity Related hypErTension (TARGET)
Status:
Completed
Trial end date:
2012-02-01
Target enrollment:
Participant gender:
Summary
High blood pressure (hypertension) is an important cause of myocardial infarction and stroke.
High blood pressure often occurs in people who are overweight. These people frequently also
have abnormal fat and sugar metabolism. The combination of these problems is called the
'metabolic syndrome'.
People with hypertension and obesity currently receive the same drug therapy as people with
hypertension, but without obesity. Different classes of drugs are thought to be equally
effective in lowering blood pressure.
Next to lowering blood pressure, hypertension treatment can have additional effects, like
changes in blood vessel function (the ability to dilate and constrict) or changes is the
metabolism of sugar and fat. Particularly in patients with the metabolic syndrome, these
additional effects are thought to be of great importance, because they can influence the risk
for cardiovascular diseases.
The blood pressure lowering mechanism differs between classes of blood pressure lowering
medication. The purpose of this study is to compare the effects of three types of blood
pressure lowering medication belonging to different classes. The main outcomes of interest
will be blood vessel function (the ability to dilate and constrict) and blood pressure.
Moreover, the effect of treatment on additional outcomes, like metabolism of sugar and fat,
will be studied.