Treatment of Alcohol-Related Hepatitis With Arginine

• Status: Withdrawn
• Trial end date: 2009-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to test the effectiveness of the amino acid arginine in reducing liver injury in individuals with alcohol-related hepatitis.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Center for Complementary and Integrative Health (NCCIH)
• Collaborator: Office of Dietary Supplements (ODS)

Criteria

Inclusion Criteria:

• Diagnosis of alcoholic hepatitis

• Maddrey's DF score less than 33

Exclusion Criteria:

• Hepatitis C or B virus infected

• HIV infected

• History of cancer

• Hepatic encephalopathy (a condition in which liver failure affects the central nervous system)

• Kidney failure

• A Do Not Resuscitate order (a patient-directed order not to resuscitate in the event that resuscitation is necessary to prevent death)

• Maddrey's DF score of 33 or greater after vitamin K administration during the study

• Alcohol withdrawal at study entry

• Active pneumonia at study entry

• Allergy to iodine

• Enrollment in any other clinical trials