Treatment of CDI and Recurrence With Fecal Microbiota Transplant Using Promicrobioma
Status:
Not yet recruiting
Trial end date:
2026-01-01
Target enrollment:
Participant gender:
Summary
The increasing inappropriate use of antimicrobials, in addition to increasing selective
pressure and inducing environmental resistance, is also a risk factor for the development of
Clostridioides difficile infection (CDI). The intestinal microbiota is mainly composed of the
phyla Firmicutes, Bacteroidetes, Acinobacteria, Proteobacteria, Fusobacteria and
Verrucomicrobia, and more than 90% of the phylum Firmicutes is composed of Clostridium spp.
(two). The inappropriate use of antimicrobials initiates a process of dysregulation of the
microbiome, called dysbiosis, and it is from the selection of genera and species of bacteria
that will dominate the intestine that pseudomembranous colitis can set in with an increased
burden of Clostridioides difficile, a gram positive, anaerobic, spore-forming, that produces
two enterotoxins, toxin A and toxin.