Overview
Treatment of Cerebral Toxoplasmosis in HIV/AIDS
Status:
Completed
Completed
Trial end date:
2004-08-01
2004-08-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
Neurological manifestations of Cerebral toxoplasmosis or Toxoplasmic encephalitis (TE) in most advance stage HIV infected patients composed of fever, headache, alteration of consciousness with focal neurological signs/symptoms such as include hemiparesis, cranial nerve palsies, and ataxia. Generalised convulsions, in ¾ of patients. Moreover meningeal irritation sign or herniation sign may be presented as life threatening conditionPhase:
Phase 4Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Rajavithi HospitalCollaborator:
Chiang Mai UniversityTreatments:
Pyrimethamine
Sulfadiazine
Trimethoprim, Sulfamethoxazole Drug Combination
Criteria
Inclusion Criteria:- AIDS
- Age > 16 years
- Clinical Diagnosis of Cerebral toxoplasmosis, Toxoplasmic encephalitis
- Positive serum titer for Toxoplasma gondii or Positive CSF titer for Toxoplasma gondii
after treatment within 2 weeks
- CT scan suspected toxoplasmosis, ring enhancing lesion
- CD4<200
Exclusion Criteria:
- Sulfa drugs allergy
- positive lymphoma cell cytology in CSF
- no informed consent by patients or first degreee relatives
- CD4 >200