Overview

Treatment of Cerebral Toxoplasmosis in HIV/AIDS

Status:
Completed
Trial end date:
2004-08-01
Target enrollment:
0
Participant gender:
All
Summary
Neurological manifestations of Cerebral toxoplasmosis or Toxoplasmic encephalitis (TE) in most advance stage HIV infected patients composed of fever, headache, alteration of consciousness with focal neurological signs/symptoms such as include hemiparesis, cranial nerve palsies, and ataxia. Generalised convulsions, in ¾ of patients. Moreover meningeal irritation sign or herniation sign may be presented as life threatening condition
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Rajavithi Hospital
Collaborator:
Chiang Mai University
Treatments:
Pyrimethamine
Sulfadiazine
Trimethoprim, Sulfamethoxazole Drug Combination
Criteria
Inclusion Criteria:

- AIDS

- Age > 16 years

- Clinical Diagnosis of Cerebral toxoplasmosis, Toxoplasmic encephalitis

- Positive serum titer for Toxoplasma gondii or Positive CSF titer for Toxoplasma gondii
after treatment within 2 weeks

- CT scan suspected toxoplasmosis, ring enhancing lesion

- CD4<200

Exclusion Criteria:

- Sulfa drugs allergy

- positive lymphoma cell cytology in CSF

- no informed consent by patients or first degreee relatives

- CD4 >200