Treatment of Children With Kidney Transplants by Injection of CD4+CD25+FoxP3+ T Cells to Prevent Organ Rejection
Status:
Unknown status
Trial end date:
2014-11-01
Target enrollment:
Participant gender:
Summary
T regulatory cells (T regs) are responsible for immune tolerance in solid organ transplant
patients. This study will evaluate the treatment of children with kidney transplants either
with Campath and other immune system suppressing medications alone or in combination with
injection of autologous CD4+CD25+CD127lowFoxP3+ T regulatory cells expanded ex vivo. The aim
of this study is to develop a new strategy that will be more effective in preventing organ
rejection and maintaining patient health.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
Pirogov Russian National Research Medical University