Treatment of Comorbid Depression and Substance Abuse in Young People

• Status: Completed
• Trial end date: 2009-05-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to treat young people with an adjunctive integrated cognitive behavioral therapy (CBT) intervention and to examine the acceptability of this treatment approach within this population. The study will also include a pilot placebo-controlled trial of sertraline for those young people who fail to or only partially respond to the CBT intervention, so as to determine whether adjunctive anti-depressant treatment improves clinical response in this population.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Dan Lubman
• Treatments: Sertraline

Criteria

Inclusion Criteria:

• 16 and 26 years of age

• acute major depressive episode (more than one month)

• concurrent DSM-IV substance abuse/dependence or the use of any illicit drug on a weekly basis in the month prior to referral, or alcohol consumption exceeding NHMRC guidelines

• English as their preferred language

• estimated IQ >80

Exclusion Criteria:

• Current or past history of psychosis

• significant head injury

• seizures

• history or current evidence of any other significant clinical condition

• treatment with an antidepressant within past 30 days