Treatment of Corneal Infiltrates Secondary to Epidemic Keratoconjunctivitis

• Status: Completed
• Trial end date: 2019-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Purpose:

To compare efficiency and tolerance between topical 0.5% cyclosporine A and fluorometholone in patients with subepithelial corneal infiltrates (SEIs).

Methods :

A prospective double-blind randomized study was conducted involving 72 eyes, 38 treated with topical fluorometholone and 34 eyes treated with cyclosporine A 0.5% eyedrops, having SEIs. Treatment was considered successful if there was reduction of SEIs and improvement in visual acuity (two snellen lines). Tolerance was mainly evaluated by Schirmer test, conjunctival hyperemia and burning sensation upon eyedrops instillation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Military Hospital of Tunis
• Treatments: Cyclosporine; Cyclosporins; Fluorometholone; Ophthalmic Solutions

Criteria

Inclusion Criteria:

• patients having subepithelial infiltrates following epidemic keratoconjunctivites persisting for 14 days or more

Exclusion Criteria:

• a past history of glaucoma or other anterior or posterior segment disease or surgery

• a chronic use of topical or systemic medications

• pregnancy,

• contact lens wearers,

• patients who couldn't attend at least two regimen visits