Treatment of Elevated Blood Pressures in Early Pregnancy

• Status: Recruiting
• Trial end date: 2024-12-31
• Target enrollment: 0
• Participant gender: Female

Summary

This is a randomized controlled trial comparing the outcomes of treatment and non-treatment of elevated blood pressures in early pregnancy.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Marshall University
• Treatments: Labetalol; Nifedipine

Criteria

Inclusion Criteria:

• Patients presenting for obstetric care at Marshall University (Huntington office and Teays Valley office) between 12 and 16 weeks gestation with a systolic blood pressure of 120 or greater OR a diastolic blood pressure of 80 or greater. Eligibility for this study will be have blood pressures between 120-139 systolic and 80-89 diastolic. Randomization to control, labetalol, or nifedipine will be performed after patient consent.

Exclusion Criteria:

• Patients already be on medication for hypertension.

• Patients with the diagnosis of chronic hypertension

• Patients with a BP of 140 or greater systolic OR 90 or greater diastolic (this meets criteria for chronic hypertension in pregnancy).

• Patients actively using any illicit substance or have history of substance use disorder.

• Patients who are actively consuming alcohol during pregnancy.

• Patients with Type I or Type II Diabetes Mellitus.

• Patients with end stage renal disease.

• Patients less then 12 weeks gestation or greater than 16 weeks