Treatment of External Genital Warts With Cryotherapy and Sinecatechins 15% Ointment
Status:
Completed
Trial end date:
2012-12-01
Target enrollment:
Participant gender:
Summary
External Genital Warts (EGW) are the most common sexually transmitted disease associated with
more than 30 types of the Human Papillomavirus (HPV). Cryotherapy is an effective method of
EGW treatment. However, multiple sessions may be required with reported clearance rates
ranging between 27-88%. Sinecatechins 15% ointment is Food and Drug Administration approved
for three times daily application in immunocompetent subjects 18 years and older for the
treatment of EGW and perianal warts. Treatment of EGW with cryotherapy followed by
sinecatechins appears to be logical. Cryotherapy has direct cytodestructive effects with
immediate short-term efficacy on treated EGW, while sinecatechins provide field therapy,
treating both clinical and sub-clinical lesions. For this study, the investigators used
sinecatechins 15% ointment twice daily regimen and anticipated that the synergistic effect
with cryotherapy will provide better efficacy that cryotherapy alone. The investigators also
anticipated that the sequential therapy with be safe.