Treatment of Fever Due to Malaria With Ibuprofen

• Status: Completed
• Trial end date: 2004-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Drugs to treat fever are widely used in children with fever. But there is a controversy about the benefit of reducing fever in children with malaria. Ibuprofen is often used to treat malarial fever. This study evaluates the capacity of ibuprofen to reduce fever in malaria. The effect of ibuprofen on fever compared to only mechanical measures is investigated in children with malaria.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Albert Schweitzer Hospital
• Treatments: Ibuprofen

Criteria

Inclusion Criteria:

• Uncomplicated falciparum malaria

• Asexual parasitaemia between 20,000 and 200,000/µL

• Fever with temperature above 38 °C or history of fever during the preceding 24 hours

• Informed consent

Exclusion Criteria:

• Effective anti-malarial treatment for the present attack

• Antipyretic use within 6 hours of presentation

• Contraindications to the use of ibuprofen (history of asthma, dyspeptic symptoms, gastro-intestinal bleeding, or allergy to ibuprofen)

• Mixed plasmodial infection

• Haemoglobin < 7 g/dL

• Packed-cell volume < 20%

• White cell count > 16,000/L

• Platelet count < 40,000/µL

• Schizontaemia > 50/µL

• Impaired consciousness

• Convulsions or history of convulsions

• Concomitant diseases masking assessment of response