Rationale:
The nocturnal blood pressure mean is an independent and stronger predictor of cardiovascular
disease (CVD) risk than either daytime office, awake or 24hour mean blood pressure. In
general, when nocturnal blood pressure does not decline CVD risk is higher, usually referred
to as "dippers" versus "non-dippers". Evening administration of treatment might lower
nocturnal blood pressure more effectively than morning administration, which is most commonly
advised.
The main hypothesis of this study is that evening administration of antihypertensive
medication might resume the dipping pattern in non-dippers and as a consequence might reduce
CVD risk more than morning administration.
Primary objective (in short):
-to prove that evening administration of enalapril/hydrochlorothiazide in non-dippers can
resume a dipping blood pressure pattern in non-dippers
Study design: A double-blind placebo-controlled cross-over study Each person will use for one
period of six weeks enalapril/hydrochlorothiazide in the morning and placebo in the evening,
and one period of six weeks the other way around
Phase:
Phase 4
Details
Lead Sponsor:
Erasmus Medical Center
Collaborator:
ZonMw: The Netherlands Organisation for Health Research and Development