Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents

• Status: Recruiting
• Trial end date: 2022-06-18
• Target enrollment: 0
• Participant gender: All

Summary

Severely brain injured patients are at high risk of intracranial hypertension. Among medical treatments (sedatives), neuromuscular blocking agents (NMBA) are recommended by french but not english speaking societies.

Effects of NMBA are unknown. The present study is designed to compare the effects of NMBA versus placebo in the treatment of intracranial hypertension, and the underlying physiopathologic effects.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Clermont-Ferrand
• Treatments: Atracurium; Cisatracurium; Neuromuscular Blocking Agents

Criteria

Inclusion Criteria:

• - Age over 18

• Mechanical ventilation and deep sedation

• Severe traumatic brain injury

• Intracranial hypertension (ICP > 20 mmHg during > 15 minutes)

• Intracranial pressure monitoring

• Hemodynamically stable

Exclusion Criteria:

• - History of anaphylaxia with neuromuscular agents

• Hemodynamic instability

• Pregnant and/or breast feeding women