Treatment of Malaria in Gabon With Fosmidomycin-Clindamycin

• Status: Completed
• Trial end date: 2003-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Some antibiotics are also effective against malaria parasites. Fosmidomycin is an antibiotic that has been shown to be effective against malaria, although it cannot achieve a total cure in all patients. A previous small study has shown that in combination with clindamycin, an commonly used antibiotic, it is highly effective and safe, in asymptomatic carriers of malaria parasites. The current study will evaluate the efficacy and safety of the combination given for three days in children with uncomplicated malaria in Gabon.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Albert Schweitzer Hospital
• Treatments: Clindamycin; Clindamycin palmitate; Clindamycin phosphate; Fosfomycin; Fosmidomycin

Criteria

Inclusion Criteria:

• Uncomplicated P. falciparum malaria with acute manifestation

• Asexual parasitemia between 1,000-100,000/μL

• Body weight between 5-65 kg

• Ability to tolerate oral therapy

• Informed consent, oral agreement of the child if appropriate

• Residence in the study area for the duration of at least 4 weeks

Exclusion Criteria:

• Adequate anti-malarial treatment within the previous 7 days

• Antibiotic treatment for a concurrent infection

• Haemoglobin <7g/dL

• Hematocrit <25%

• Leukocyte count >15,000/μL

• Mixed plasmodial infection

• Severe malaria, any other severe underlying disease

• Concomitant disease masking assessment of treatment response

• Inflammatory bowel disease, and any other disease causing fever.