Treatment of Menstrual Migraine With Sequential, Transdermal, 17-Beta-Estradiol. A Double-Blind, Randomised, Cross-Over Trial.

• Status: Unknown status
• Trial end date: 2005-07-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to determine whether transdermally administered 17-beta estradiol sequentially could reduce the number of, and severity of, menstrual migraine attacks.

• Phase: Phase 2/Phase 3

Details

• Lead Sponsor: University Hospital, Linkoeping
• Treatments: Estradiol; Estradiol 17 beta-cypionate; Estradiol 3-benzoate; Estradiol valerate; Polyestradiol phosphate

Criteria

Inclusion Criteria:

• Migraine only during the menstrual period

• Migraine attacks each menstrual period during the last year

• Regular menstrual cycle

Exclusion Criteria:

• Migraine other times than during the menstrual period

• Use of hormonal contraceptives (other than depo-provera)during the last three months.

• Depo-provera injection the last year

• History of Thrombo-embolism

• Liver disease

• History of malignancy

• Breast-feeding during the last two months

• Abortion/miscarriage during the last two months

• Pregnancy