Treatment of Mild Hypertension Study (TOMHS)

• Status: Completed
• Trial end date: 1994-05-01
• Target enrollment: 0
• Participant gender: All

Summary

To compare the effects of nonpharmacologic therapy alone with those of one of five active drug regimens combined with non-pharmacologic therapy, for long- term management of patients with mild hypertension.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Minnesota; University of Minnesota - Clinical and Translational Science Institute
• Collaborator: National Heart, Lung, and Blood Institute (NHLBI)
• Treatments: Acebutolol; Amlodipine; Chlorthalidone; Doxazosin; Enalapril

Criteria

Men and women, ages 45 to 69, with mild hypertension (diastolic blood pressure of 90-99 mm Hg at two of three visits for untreated individuals. Patients who received drug therapy must have had a DBP less than 95 mm Hg two to four weeks after drug.