Treatment of Mood and Marriage Study (TOMMS)

• Status: Completed
• Trial end date: 2010-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary goal of this study is to develop and test a depression-specific marital therapy tailored for use with older adult populations.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Duke University
• Collaborator: National Institutes of Health (NIH)
• Treatments: Bupropion; Lithium Carbonate; Nortriptyline; Sertraline; Tranylcypromine; Venlafaxine Hydrochloride

Criteria

Inclusion Criteria:

• One partner must receive a clinical diagnosis of major depressive disorder based upon our assessment

• Couples must be living together

• Either partner must report marital distress or tension

• Willing to take antidepressant medication and participate in weekly marital therapy and assessments

• The depressed partner cannot be involved in any other psychosocial treatment

• Score above 24 on the Mini Mental Status Exam

Exclusion Criteria:

• Both partners meet diagnostic criteria for major depressive disorder based on our evaluation

• Coexisting bipolar or psychotic disorder

• Evidence of a primary substance abuse or dependence disorder

• Current ECT treatment

• Evidence of active and severe domestic violence