Treatment of Muscle Cramps in Patients With Liver Cirrhosis

• Status: Completed
• Trial end date: 2015-04-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a pilot study to see if hydroxychloroquine (HCQ) if safe and effective to use with patients having cramps due to their cirrhotic liver disease.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mayo Clinic
• Treatments: Hydroxychloroquine

Criteria

Inclusion Criteria:

• previous diagnosis of cirrhosis

• adult (>21 years)

• able to complete a written questionnaire in English

• stable and ambulatory

• MELD score < 25, Platelet count >25,000

Exclusion Criteria:

• people allergic to hydroxychloroquine, 4-aminoquinolone derivatives or any component of the formulation

• previous diagnosis of retinal or visual field changes attributable to 4-aminoquinolone

• previous diagnosis of porphyria

• previous diagnosis of psoriasis

• fulminant hepatic failure

• pregnant women