Treatment of Non-Anemic Iron Deficiency in Pregnancy

• Status: Not yet recruiting
• Trial end date: 2023-11-15
• Target enrollment: 0
• Participant gender: Female

Summary

The objective is to investigate the treatment of non-anemic iron deficiency (NAID) and the impact on development of anemia later in pregnancy. Anemia in the third trimester has been identified as a risk factor for maternal and fetal morbidity that might lead to mortality. Due to the high incidence of NAID in pregnancy, there is an opportunity for early screening and treatment to decrease progression to anemia. The primary aim of this study is to establish if treatment of NAID will result in higher third trimester hemoglobin values and decrease incidence of anemia at term.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Stony Brook University
• Treatments: Ascorbic Acid; Bismuth subsalicylate

Criteria

Inclusion Criteria:

• English speaking

• age 18-55

• less than 20 weeks gestational age

• low ferritin level (<30mcg/L) in the first trimester

• normal hemoglobin level (>11g/dL) in the first trimester

Exclusion Criteria:

• Women with anemia diagnosed in the first trimester (HgB ≤11 g/dL)

• Women with antepartum iron supplementation, except prenatal vitamin, within 3 months

• Women with iron overload or hypersensitivity

• Women with significant vaginal bleeding prior to enrollment

• Women with chronic illness: SLE, hemoglobinopathies, HIV, inflammatory bowel disease, active cancer, prior bariatric surgery