Treatment of Orthostatic Hypotension in Autonomic Failure

• Status: Completed
• Trial end date: 2017-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The autonomic nervous system serves multiple regulatory functions in the body, including the regulation of blood pressure and heart rate, gut motility, sweating and sexual function. There are several diseases characterized by abnormal function of the autonomic nervous system. Medications can also alter autonomic function. Impairment of the autonomic nervous system by diseases or drugs may lead to several symptoms, including blood pressure problems (e.g., high blood pressure lying down and low blood pressure on standing), sweating abnormalities, constipation or diarrhea and sexual dysfunction. Because treatment options for these patients are limited. We propose to study patients autonomic failure and low blood pressure upon standing and determine the cause of their disease by history and examination and their response to autonomic testing which have already been standardized in our laboratory. Based on their possible cause, we will tests different medications that may alleviate their symptoms.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Vanderbilt University; Vanderbilt University Medical Center
• Treatments: Acarbose; Acetazolamide; Armodafinil; Atomoxetine Hydrochloride; Bromides; Caffeine; Carbidopa; Carbidopa, levodopa drug combination; Celecoxib; Diphenhydramine; Ephedrine; Ergotamine; Ibuprofen; Indomethacin; Levodopa; Methylphenidate; Midodrine; Modafinil; Octreotide; Oxymetazoline; Phenylephrine; Promethazine; Pseudoephedrine; Pyridostigmine Bromide; Ranitidine; Ranitidine bismuth citrate; Rivastigmine; Tranylcypromine; Yohimbine

Criteria

Inclusion Criteria:

• Patients referred for evaluation of their autonomic function

• Ages 18-85

Exclusion Criteria:

• Pregnancy