Treatment of Orthostatic Hypotension

• Status: Completed
• Trial end date: 2020-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to try different medications in patients with low blood pressure and other problems with their involuntary (autonomic) nervous system. The pharmacological trials in this study will perhaps lead to more effective treatment. This study consists of single dose trials, dose selection trials, 5-day trials and chronic (approximately 2 months) trials.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Vanderbilt University; Vanderbilt University Medical Center
• Treatments: alpha-Methyltyrosine; Atomoxetine Hydrochloride; Carbidopa; Droxidopa; Levodopa; Methyldopa; Metoclopramide

Criteria

Inclusion Criteria:

• patients with severe orthostatic hypotension and other autonomic symptoms who do not meet criteria for one of our standard diagnoses

• non-smokers

• drug-free

• able to give informed consent

• free of pulmonary, renal, hematopoietic, hepatic and cardiac disease

Exclusion Criteria:

• medications affecting the autonomic nervous system

• any chronic illness (cardiac, pulmonary, endocrine, gastrointestinal, rheumatologic)

• anemia (Hct < 30)

• women of childbearing age who are pregnant or nursing

• smokers