Treatment of Orthostatic Intolerance in Patients With Parkinson's Disease Using Midodrine
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
This study will evaluate whether treatment with the α1-agonist, midodrine, reduces subjective
orthostatic lightheadedness as measured by the Non-Motor Symptoms Scale for Parkinson's
Disease (NMSS) questionnaire, in patients with (positive control group, OH) or without
documented orthostatic hypotension(orthostatic intolerance, OI). It will also demonstrate the
effect of treatment with an α1-agonist, midodrine, on beat-to-beat blood pressure and heart
rate response during Valsalva maneuver (measured by Continuous Non-invasive Arterial
Pressure, CNAP) in patients with OI or OH and evaluate the relationship to symptom
improvement.