Treatment of PTSD by Reduction of Traumatic Memory Reconsolidation by Propranolol : a Multisite Trial

• Status: Completed
• Trial end date: 2017-06-30
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to test whether propranolol, when given during a re-evocation of a traumatic memory, is capable of reducing subsequent PTSD symptoms associated with that memory.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Toulouse
• Treatments: Propranolol

Criteria

Inclusion Criteria:

• Diagnosis of chronic PTSD

• PTSD CheckList total score >44

Exclusion Criteria:

• Systolic blood pressure < 100 mmHg

• Contraindication to Propranolol

• Previous adverse reaction to a β-blocker

• Use of another β-blocker

• Use of medication that could involve potentially dangerous interactions with propranolol

• Psychotherapy or treatment with any pharmacologic PTSD medication within the 2 weeks prior to inclusion (6 weeks for fluoxetine)

• Female with reproductive potential without reliable means of contraception

• Pregnancy or lactation

• Alcohol or drug abuse