Treatment of Patients Colonized With Methicillin-Resistant Staphylococcus Aureus Prior to Bone and Joint Surgery

• Status: Withdrawn
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators anticipate that utilization of retapamulin preoperatively will eliminate MRSA colonization among patients who are colonized in their nares.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Bay Pines VA Healthcare System
• Treatments: Methicillin; Retapamulin

Criteria

Inclusion Criteria:

• Patients who are admitted for an orthopedic surgical procedure

• All patients will be screened and admitted to the study prior to surgery regardless of eventual culture results for MRSA

Exclusion Criteria:

• Pregnancy

• Serious systemic illness due to renal, cardiac or hepatic disease

• Inability to complete follow-up assessments

• Allergy or intolerance to retapamulin

• BMI > 30

• Uncontrolled diabetes, severe anemia, thrombocytopenia or an underlying hematopoietic disorder or malignancy

• Patients with serious life-threatening illnesses and those with terminal illness not expected to survive for two years or more will not be enrolled

• Antibiotics administered during the course of the study will be recorded (name, dose and dates)