Treatment of Persistent Wheezing in Infants and Children

• Status: Completed
• Trial end date: 2007-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Wheezing is a high-pitched whistling sound that is produced when air flows through narrowed lung airways. It is a common symptom of asthma. Persistent wheezing is commonly treated with bronchodilators and inhaled steroids; however, when wheezing is temporarily caused by a virus or exposure to tobacco smoke, this may not be the most effective treatment. The purpose of this study is to evaluate the cause of wheezing in infants and children and to assess the effectiveness of inhaled steroids on improving lung function.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
• Treatments: Fluticasone

Criteria

Inclusion Criteria:

• Moderate to severe persistent wheezing, as defined by the National Asthma Education and Prevention Program Expert Panel Report 2

• No signs of upper or lower respiratory tract infection for at least two weeks prior to study entry

Exclusion Criteria:

• Received therapy with inhaled corticosteroids in the month prior to study entry

• History of seizures or other neurologic disorders

• Hypoxemia requiring supplemental oxygen to maintain oxygen saturation above 90%

• Sepsis

• Underwent a tracheostomy

• Heart disease

• Suspected or documented pulmonary hypertension

• Currently undergoing assisted ventilation

• Born at less than 36 weeks gestation