Treatment of Polytraumatisms With Corticoids

• Status: Completed
• Trial end date: 2009-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Interest of treatment of polytraumatisms with corticoids (hydrocortisone) for patient with relative adrenocortical insufficiency on frequency of nosocomial infection, and hemodynamic complications and organs injuries.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Nantes University Hospital
• Collaborator: Serb
• Treatments: Cortisol succinate; Hydrocortisone; Hydrocortisone 17-butyrate 21-propionate; Hydrocortisone acetate

Criteria

Inclusion Criteria:

• Age superior of 15 years

• Hospitalization in reanimation for polytraumatism (lesion of two organs with a vital risk)

• SISS score more than 15

• Intubation for more than 48 hours.

• Agreement of a family member

• Patient with insurance

Exclusion Criteria:

• History of corticothérapies within 6 months

• History of adrenocortical insufficiency.

• Treatment by immunosuppressor

• Immunodeficiency.