Treatment of Refractory Status Epilepticus

• Status: Terminated
• Trial end date: 2010-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether propofol or barbiturates should be preferred in the treatment of status epilepticus (continuous seizure activity) refractory to 2 standard antiepileptic agents.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Brigham and Women's Hospital
• Treatments: Pentobarbital; Propofol; Thiopental

Criteria

Inclusion Criteria:

• Patients with refractory status epilepticus not due to cerebral anoxia, needing coma induction for clinical management.

Exclusion Criteria:

• Age < 16 years old.

• Known pregnancy.

• Cerebral anoxia as SE etiology.

• Epilepsia partialis continua (simple partial SE).

• Known intolerance to the study drugs.

• Known mitochondrial disorder, hyperlipidemia, or significant rhabdomyolysis.