Treatment of Tumors of the Choroid Plexus Epithelium
Status:
Terminated
Trial end date:
2017-12-14
Target enrollment:
Participant gender:
Summary
The goal of this clinical research study is to compare carboplatin to cyclophosphamide when
given with etoposide, vincristine, and radiation therapy in the treatment of choroid plexus
tumors. The safety of these 2 combination therapies will also be compared.
Objectives:
OVERALL AIM:
To improve choroid plexus tumor treatment through better understanding of the tumor biology
and through increased knowledge about the benefit of specific treatment elements.
Specific Objectives:
The study will have a prephase to evaluate the feasibility of the following randomized study
(main phase).
Pre-Phase (completed 2005) Primary Specific Objective:
To determine the number of patients accountable per year for randomization in a worldwide
study.
Secondary Specific Objective:
To measure the number of drop outs and to describe the toxicity of the chemotherapy.
Main Phase (started in 2006) Primary Specific Objective:
To compare the survival times after cyclophosphamide based treatment with the survival times
after carboplatin based treatment in choroid plexus tumor patients.
Main Phase Secondary Specific Objectives:
1. To compare the resectability of choroid plexus tumors after two blocks of
cyclophosphamide based treatment with the resectability after two blocks of carboplatin
based treatment.
2. To compare response rates of incompletely resected choroid plexus tumors to two blocks
of cyclophosphamide based treatment with the response rates after two blocks of
carboplatin based treatment.
3. To determine the prognostic relevance of histological atypia and SV40 in choroid plexus
tumors.