Treatment of Type-1 Hepatorenal Syndrome Associated With Sepsis
Status:
Completed
Trial end date:
2013-08-01
Target enrollment:
Participant gender:
Summary
Type 1 Hepatorenal syndrome (type-1 HRS) is a severe complication of patients with advanced
cirrhosis characterized by marked renal failure and is associated with a very poor prognosis.
Type-1 HRS is often precipitated by a bacterial infection, though it may occur spontaneously.
It has been demonstrated that vasoconstrictor agents plus albumin are effective in the
reversal of the renal failure. A large number of studies have shown that terlipressin
improves renal function in patients with type 1 HRS; treatment is effective in 50-75% of
patients approximately. Currently there are no specific studies about the treatment of type-1
HRS with ongoing infections.