Treatment of a Cancerous Disease of the Peritoneum With Complete Cytoreductive Surgery and Intraperitoneal Chemohyperthermia

• Status: Terminated
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the treatment of a cancerous disease of the peritoneum with complete cytoreductive surgery with intraperitoneal chemohyperthermia using oxaliplatin plus irinotecan.

This is a Phase II study with 100 patients. Origins of the tumors: these include colon, rectum, appendix, peritoneum, and endocrine tumors.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Gustave Roussy, Cancer Campus, Grand Paris
• Treatments: Irinotecan; Oxaliplatin

Criteria

Inclusion Criteria:

• Peritoneal seedings coming from colon, rectum, pseudomyxoma (appendix), peritoneum (mesothelioma and serous tumors), or endocrine tumors.

• No extra-abdominal metastases

• Good general status (American Society of Anesthesiologists Physical Status score [ASA] 1 or 2)

• Signed consent

Exclusion Criteria:

• Tumor seedings coming from other origins

• Huge peritoneal carcinomatosis (peritoneal score > 25, except for pseudomyxomas)

• Peritoneal carcinomatosis progressing rapidly

• Presence of extra-abdominal metastases

• Patients presenting contraindications to the use of oxaliplatin or irinotecan