Treatment's Duration of Acute Uncomplicated Pyelonephritis

• Status: Completed
• Trial end date: 2011-08-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to compare the efficacy of 5 days versus 10 days treatment duration in uncomplicated acute pyelonephritis.

Acute pyelonephritis is a common disease and the treatment duration is not found on scientific evidence. If a short treatment is equal to standard duration, it will possible to shortening antibiotherapy with ecologic and economic advantage.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Treatments: Ciprofloxacin; Fluoroquinolones; Levofloxacin; Ofloxacin

Criteria

Inclusion Criteria:

• Women 18 to 65 years old

• Non-immunocompromised

• Conducting a medical examination prior

• Signature of informed consent in writing.

• Clinical signs of urinary tract infection (urinary burning, urgency, pollakiuria, dysuria, pyuria, lumbar or pelvic pain),

• A temperature> 38 ° C,

• A positive ECBU direct seed (s) sensitive (s) to the fluoroquinolones

Exclusion Criteria:

• Antibiotic therapy prior

• Presence of complications of PNA (abscesses, dilated excretory pathways, probe urinary bladder, neurological, transplant, kidney single functional or anatomical),

• An episode of PNA within 6 months,

• having fluoroquinolones in 6 months,

• Infection on urinary endo-material (prosthetic urethral, ureteral probe)

• The immunodepressed (known seropositivity for HIV, asplenia, diabetes neutropenia, agammaglobulinemia ...)

• Pregnancy and lactation,

• Allergy to antibiotics,

• Corticosteroids concomitantly taking fluoroquinolones,

• History of TENDINOPATHY with a fluoroquinolone

• History of epilepsy

• Deficit known as glucose-6-phosphate dehydrogenase

• Life expectancy <1 month

• Cognitive major

• Patient under guardianship, CURATORSHIP or without coverage,

• The need for immunosuppressive or corticosteroid therapy,

• The need for other concomitant antibiotic treatment, whatever the cause

• No affiliation to a social security scheme (beneficiary or beneficiary).