Trial Assessing the Effect of Preoperative Furosemide on Intraoperative Blood Pressure

• Status: Completed
• Trial end date: 2007-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether continuing or discontinuing furosemide (a diuretic) on the day of elective noncardiac surgery for those who take furosemide on a chronic basis, causes more intraoperative hypotension (low blood pressure) during surgery. Our hypothesis is that the usual practice of continuing furosemide on the day of surgery would contribute to more hypotension during surgery than discontinuing furosemide.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Calgary
• Collaborator: The Centre for the Advancement of Health
• Treatments: Furosemide

Criteria

Inclusion Criteria:

• All adults referred to preoperative assessment clinics by surgeons for elective non-cardiac surgery who routinely take furosemide.

• Participants must also be able to give informed consent

Exclusion Criteria:

• Less than 18 years of age

• Have comorbid conditions with which brief periods of hypotension may be particularly harmful such as: 1) pregnancy; 2) baseline hypotension (systolic <100 mmHg at the preoperative assessment clinic); 3) autonomic dysfunction; 4) severe aortic stenosis.

• Patients who take furosemide only on an 'as needed basis' rather than 'regularly'.

• Those patients who take less than 10 mg of furosemide daily

• Those patients who are undergoing local anesthetic only surgical procedures

• Patients who are unwilling or unable to give informed consent.