Trial Assessing the Efficacy of a Short Course of Intravenous Antibiotic Followed by Oral Antibiotic in Uncomplicated Acute Diverticulitis

• Status: Completed
• Trial end date: 2008-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Medical treatment of uncomplicated acute diverticulitis is not standardized and there is an enormous diversity in clinical practice. The investigators' aim was to demonstrate that uncomplicated diverticulitis can be managed with oral amoxicillin plus clavulanic acid with a short hospital admission.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Consorci Sanitari de Terrassa
• Collaborator: Corporacion Parc Tauli
• Treatments: Amoxicillin; Anti-Bacterial Agents; Antibiotics, Antitubercular; Clavulanic Acid; Clavulanic Acids

Criteria

Inclusion Criteria:

• clinical diagnosis of uncomplicated acute diverticulitis confirmed by a computed tomography (CT) scan within 24-48 hours

Exclusion Criteria (prerandomization):

• immunocompromised patients

• pregnant women

• clinical suspicion or CT confirmation of complicated acute diverticulitis

• Karnofsky performance score less than 50%

• allergy to penicillin

Exclusion Criteria (postrandomization):

• withdrawal of the trial

• CT confirmation of complicated acute diverticulitis

• CT not conforming to acute diverticulitis

• CT performed 72 hours after the admission

• adverse reaction to the antibiotic

• bacteriemia