Trial Evaluating Adapted Chemotherapy in Patients With Squamous Carcinoma

• Status: Recruiting
• Trial end date: 2021-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this study is to evaluate the efficacity of the combination of cisplatin-5-FU and docetaxel in adapted doses in term of response to treatment without toxicity

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• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Groupe Oncologie Radiotherapie Tete et Cou
• Collaborator: Centre Leon Berard
• Treatments: Docetaxel; Fluorouracil

Criteria

Inclusion Criteria:

1. Histologically proven squamous cell carcinoma of the head and neck from one or more of the following primary sites: oral cavity, oropharynx, hypopharynx or larynx, lymphadenopathy without front door

2. Inoperable tumor or tumor whose surgery would be multilating.

The non-operability criteria are:

• Technically impossible resection: fixation / invasion of the tumor at the base of the skull or at the cervical vertebrae, nasopharynx involved, lymph nodes

• Medical selection based on low surgical curability. This category includes all T3-T4 and all N2-N3 (AJCC 8th edition, June 2018)

• Medical selection based on an organ preservation strategy

3. Patient not previously treated for ORL cancer

4. Age > 18 and < 75 years

5. PS 0 or 1 according to WHO

6. At least one lesion measurable according to the RECIST 1.1 criteria

7. Patient who can receive TPF according to the following criteria:

• Adequate hematological function: neutrophils ³ 1.5 x 109 / l, platelets ³ 100 x 109 / l, hemoglobin ³ 10 g / dl (or 6.2 mmol / l)

• Adequate renal function: calculated creatinine clearance (Cockroft & Gault) or measured ³ 60 ml / min.

• Adequate liver function: normal total bilirubin; ASAT and ALAT less than or equal to 1.5 ´ LNS; PAL less than or equal to 2.5 X LNS

• Grade <2 peripheral neuropathy according to NCI CTCAE v5.0

• No clinical impairment of hearing function

• For patients aged 71 to 74, PS at 0 and considered non-geriatrically fragile (G8 questionnaire and multidimensional assessments proposed by the GERICO group (ADL, MMSE, GDS scale, nutrition, motor skills and balance, geographic and personal situation and assessments) thymic))

8. Estimated life expectancy greater than or equal to 3 months

9. Weight loss of less than 10% during the 3 months before randomization

10. Patient understanding French and able to complete quality of life questionnaires

11. Patient having given written consent before any specific protocol procedure

12. Affiliation to a social security scheme or beneficiary of such a scheme

Exclusion Criteria:

1. Trans-glottic T3 with massive infiltration of the hemilarynx or T4 with massive cartilage lysis or tumor of the retro-cricoarythenoid region or of the posterior hypopharyngeal wall

2. Vaccination against recent or planned yellow fever

3. Known deficiency in dihydropyrimidine dehydrogenase (DPD) or determined by the determination of uricemia.

4. History of other cancer except in situ cervical cancer or controlled basal cell carcinoma. Patients in remission from cancer treated more than 3 years ago are eligible. Patients treated by surgery alone for ORL cancer in the previous 3 years are eligible.

5. Previous treatment of an ORL cancer by chemotherapy or radiotherapy Patients treated by surgery alone for ORL cancer in the previous 3 years are eligible).

6. Presence of distant metastasis.

7. Participation in a therapeutic trial in the 30 days preceding randomization

8. Concomitant anticancer treatment

9. Patient under chronic treatment (3 months) with corticosteroid whose daily dosage is 20 mg / day of methylprednisolone or equivalent

10. Other existing serious medical pathologies (non-exhaustive list):

• Uncontrolled cardiac pathology despite adequate treatment

• Myocardial infarction in the 6 months preceding randomization

• Neurological or psychiatric history such as dementia, convulsions

• Active infection

• Significant gastrointestinal abnormalities, including those that require parenteral nutrition, active peptic ulcer, and history of surgeries affecting absorption

• Obstructive pulmonary disease requiring hospitalization in the year preceding randomization

• Uncontrolled type II diabetes or other corticosteroid contraindications.

• Moderate or severe eczema

11. Known hypersensitivity to docetaxel, cisplatin 5FU or one of their excipients.

12. Intended concomitant use of phenytoin, carbamazepine, barbiturates or rifampicin

13. Presence, upon selection, of psychological, family, social or geographic factors likely to influence the patient's compliance with the study and monitoring protocol.

14. Pregnant or lactating woman

15. Patient (male or female) of reproductive age who is unable or unwilling to take adequate contraceptive measures during treatment and up to 6 months after the last treatment is administered.

16. Persons deprived of their liberty, under guardianship or curatorship