Trial in Periodontal Tissue Regeneration Using Fibroblast Growth Factor-2

• Status: Completed
• Trial end date: 2004-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The present clinical trial clarified that basic fibroblast growth factor-2 (FGF-2) can induce regeneration of periodontal tissue lost by progression of periodontitis and evaluated the safety of such induction.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kaken Pharmaceutical
• Treatments: Mitogens

Criteria

Inclusion Criteria:

• diagnosed as 2- or 3-walled vertical intrabony defect >=3 mm deep from the top of the remaining alveolar bone

• with mobility of the tooth of degree 2 or less

• with width of attached gingiva appropriate for Guided Tissue Regeneration

Exclusion Criteria:

• concomitant administration of adrenal cortical steroid within 4 wks after the surgery

• administeration of calcium antagonist during the 4 weeks preceding administration of the investigational drug

• coexisting malignant tumour or history of the same

• coexisting diabetes (HbA1C >= 6.5%)

• an extremely poor nutritional condition (serum albumin concentration <2 g/dL)

• pregnancy or lactation