Trial of Celecoxib With Preoperative Chemo- Radiation for Locally Advanced Rectal Cancer
Status:
Completed
Trial end date:
2013-04-01
Target enrollment:
Participant gender:
Summary
This is a single arm phase II trial with combined celecoxib, tegafur-uracil, folinate and
preoperative radiotherapy for patients with locally advanced rectal cancer. The primary end
point is pathological complete response (pCR) rate. The secondary endpoints are toxicities of
combined celecoxib and chemoradiation, negative resection margin rate, clinical tumor
response by magnetic resonance imaging (MRI), sphincter preservation rate, disease-free
survival and overall survival.
Phase:
Phase 2
Details
Lead Sponsor:
National Health Research Institutes, Taiwan
Collaborators:
Chang Gung Memorial Hospital Changhua Christian Hospital Chi Mei Medical Hospital Mackay Memorial Hospital National Cheng-Kung University Hospital Taichung Veterans General Hospital Taipei Veterans General Hospital, Taiwan