Trial of Chemotherapy and Avastin as Treatment for Women With Breast Cancer at High Risk for Relapse
Status:
Terminated
Trial end date:
2014-01-01
Target enrollment:
Participant gender:
Summary
Women with breast cancer who are not eligible for breast conserving surgery or who have
node-involvement are sometimes treated with chemotherapy up front, in hopes of allowing for a
woman to keep her breast and decreasing the size of the excision for her breast cancer. While
current research has shown that survival is the same whether women are treated with
chemotherapy first or surgery first for breast cancer, the investigators do not yet know how
to treat women with persistent breast cancer after she has received primary chemotherapy.
This study looks at the use of a combination regimen of two agents (gemcitabine and
capecitabine), both of which are active in breast cancer, and using Avastin to see if this
regimen can be given to women treated with primary chemotherapy and then surgery, considered
to be at high risk of relapse.
Phase:
Phase 2
Details
Lead Sponsor:
Brown University
Collaborators:
Memorial Hospital of Rhode Island Rhode Island Hospital The Miriam Hospital University of New Mexico Cancer Center Women and Infants Hospital of Rhode Island