Trial of Chemotherapy in Ovarian, Fallopian Tube and Peritoneal Carcinoma
Status:
Completed
Trial end date:
2019-10-11
Target enrollment:
Participant gender:
Summary
This is a prospective study to evaluate the hypothesis that platinum-based neoadjuvant
chemotherapy followed by interval surgical debulking with platinum-based adjuvant
chemotherapy is associated with improved maximal surgical cytoreduction rates, comparable
survival, decreased morbidity, and increased quality of life in patients with International
Federation of Gynecologic Oncology stages IIIC and IV ovarian, primary peritoneal, or
fallopian tube cancer when compared to historical controls and to evaluate the hypothesis
that cancer induced inflammation is a predictor of poor prognosis and response to therapy in
this group of ovarian cancer patients.