Trial of Clopidogrel After Surgery for Coronary Artery Disease (CASCADE Trial)

• Status: Completed
• Trial end date: 2009-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether the combination of clopidogrel with aspirin prevents the development of blockages (atherosclerosis) in vein grafts one year after coronary artery bypass surgery (CABG) compared to aspirin alone.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ottawa Heart Institute Research Corporation
• Collaborators: Bristol-Myers Squibb; Sanofi
• Treatments: Clopidogrel; Diuretics; Ticlopidine

Criteria

Inclusion Criteria:

• Patients undergoing primary multi-vessel CABG with at least two saphenous vein grafts, with or without the use of cardiopulmonary bypass.

Exclusion Criteria:

• Emergency surgery

• Valve surgery

• Redo CABG

• Left ventricle ejection fraction < 25%

• Serum creatinine > 130 µmol/L

• Preoperative use of clopidogrel (with the exception of the current admission)

• Preoperative use of warfarin; allergy to aspirin or clopidogrel.

• History of cerebrovascular accident

• History of severe liver disease

• Morbid obesity

• Current malignancy