Trial of Diphenhydramine for Sleep in Children With Autism
Status:
Not yet recruiting
Trial end date:
2027-06-30
Target enrollment:
Participant gender:
Summary
The purpose of this study is to examine the effect of diphenhydramine on sleep in children
and adolescents with Autism Spectrum Disorder (ASD). Diphenhydramine is an anti-histaminergic
agent with strong hypnotic properties. To accomplish this, we will use a randomized
double-blind placebo-controlled crossover 8-week study design to examine the effect of
diphenhydramine on sleep physiology as assessed by polysomnography (PSG), actigraphy,
circadian rhythm, and clinical measures.