Trial of Liposomal Versus Plain Bupivacaine in Minimally Invasive General Surgery Procedures

• Status: Unknown status
• Trial end date: 2018-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Aim: To compare the postoperative outcomes after surgical infiltration with plain bupivacaine compared to liposomal bupivacaine in patients undergoing elective, minimally invasive, general surgery procedures. To the investigators knowledge, there are no head-to-head, prospective, randomized, controlled trials of plain bupivacaine versus liposomal bupivacaine to evaluate postoperative pain and return of function.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: United States Naval Medical Center, San Diego
• Treatments: Bupivacaine

Criteria

Inclusion Criteria:

• Age: 18 years or older

• ASA status 1, 2 or 3

• Having an elective, minimally invasive, general surgery procedure at NMCSD

Exclusion Criteria:

• Age: Younger than 18 years old

• Pregnant women - safety of liposomal bupivacaine has not been studied in pregnant women

• ASA status greater than or equal to 4

• Conversion to open procedure/laparotomy

• History of reaction to local anesthetics

• History of hepatic disease - local anesthetics are metabolized in the liver

• History of pre-operative/concurrent condition requiring narcotic use

• Patient not able to adhere to post-operative pain control regimen outlined in methods section