Trial of Magnesium Sulfate Tocolysis Versus Nifedipine Tocolysis in Women With Preterm Labor

• Status: Terminated
• Trial end date: 2009-10-01
• Target enrollment: 0
• Participant gender: Female

Summary

Primary Hypothesis:

Acute tocolysis (48 hours) using oral nifedipine is more effective than intravenous magnesium sulfate in prolonging pregnancy in women with preterm labor with intact membranes between 24 and 32 6/7 weeks' gestation.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Cincinnati
• Collaborator: University Hospital
• Treatments: Magnesium Sulfate; Nifedipine

Criteria

Inclusion Criteria:

• Women in preterm labor between 24 to 32 6/7 weeks' gestation with intact membranes with an age range of 15 to 50 years old.

Exclusion Criteria:

• Cervical dilatation of ≥ 6 cm

• Maternal contraindication to tocolysis

• Known fetal anomalies

• Suspected chorioamnionitis

• Nonreassuring fetal heart tracing

• Vaginal bleeding due to placenta previa or abruptio placenta

• Preterm premature rupture of membranes

• Prolapsed membranes

• Human immunodeficiency virus positive

• Multiple gestation

• Patients on procardia within 24 hours of po intake

• Magnesium sulfate tocolysis prior to randomization

• Patient refusal