Trial of Mesalamine for the Treatment of Active Microscopic Colitis

• Status: Completed
• Trial end date: 2007-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Subjects must be 18 years old and older, have diarrhea and microscopic colitis. Pregnant or nursing females are excluded. They can't have other untreated diarrheal conditions. Subjects will receive medication for 8 weeks, followed by sigmoidoscopy with biopsies. The subjects will be monitored weekly. A pathologist will review pre and post treatment biopsies. Subjects that show improvement will be followed for 4 weeks post medication.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mayo Clinic
• Collaborators: Edward V. Loftus MD; Paul E. Evans MD; Thomas C. Smryk MD; Willaim Tremaine MD; William J. Sandborn MD
• Treatments: Mesalamine

Criteria

Inclusion Criteria:

• Subjects must be 18 years old and older.

• Have diarrhea and microscopic colitis.

• They need to have a colon biopsy done at the Mayo Clinic in Rochester, MN within a year of enrollment.

Exclusion Criteria:

• None.