Trial of Naproxen to Evaluate Various Methods of Measuring Analgesic Effect in Osteoarthritis Pain of the Knee
Status:
Unknown status
Trial end date:
2012-06-01
Target enrollment:
Participant gender:
Summary
This study aims to evaluate various methods of measuring pain relief in subjects who have
chronic OA of the knee. After a 1 week of wash-out from existing therapy, subjects will be
treated in a blinded fashion for 1 week with either naproxen (3 days at 250 mg twice a day
followed by 4 days at 500 mg twice a day) or placebo. After the first week of treatment,
subjects will have another week of wash-out followed by a second period of 1 week of the
alternate treatment. Subjects will not be allowed to use oral non-steroidal anti-inflammatory
drugs (NSAIDs) or other oral analgesics, or topical medications on their target knees during
the study. Acetaminophen will be allowed as a rescue medication.