Trial of Probiotics for Constipation in Parkinson's Disease

• Status: Completed
• Trial end date: 2019-01-31
• Target enrollment: 0
• Participant gender: All

Summary

This is a double blinded randomised placebo controlled trial to evaluate the efficacy of probiotics in the treatment of constipation in Parkinson's disease.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Malaya

Criteria

Inclusion Criteria:

• Age 50 to 80 years old

• Provision of written informed consent

• Diagnosis of PD made by a Neurologist using UK Brain Bank Criteria

• Fulfils criteria for functional constipation according to the Rome IV Criteria during in the preceding 6 months with frequency of bowel movements less than 3 times per week

Exclusion Criteria:

• Ingestion of probiotics in the preceding 4 weeks

• Use of antibiotics in the preceding 4 weeks

• History of gastrointestinal disorders or surgery

• Known or suspected allergy to probiotics

• Comorbidities that prevent reliable completion of study assessments

• Prior functional neurosurgery for PD or treatment with apomorphine infusion

• Recent initiation of dopaminergic medications in the preceding 3 months