Trial of Sirolimus and Methotrexate in Relapsed/Refractory Lymphoblastic Leukemia and Lymphoma
Status:
Completed
Trial end date:
2017-02-01
Target enrollment:
Participant gender:
Summary
This is a phase 2 study looking at efficacy and toxicity of oral sirolimus in combination
with oral methotrexate in children with refractory/relapsed ALL or NHL.
Secondary objectives include characterizing the trough levels produced by administration of
oral sirolimus in children with refractory/relapsed ALL/NHL and to evaluate the effect of
sirolimus on intracellular targets related to mTOR inhibition.